Delayed-Onset Cyst Formation After Laser Interstitial Thermal Therapy: Unreported Long-Term Complication.
case_report · Level V
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- Record sourced from PubMed, PMID 30639484.
- Also identified by DOI 10.1016/j.wneu.2018.12.148.
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Abstract
The majority of complications following (LITT) therapy occur in the early postoperative period, with few long-term complications being reported. Here we present 2 cases of delayed-onset cyst formation occurring more than 1 year following ablation, a previously unreported complication. In the first case, a 59-year-old female who previously underwent LITT for a radiation-induced cavernoma developed a 2-cm cystic lesion 18 months after ablation, resulting in recurrent seizures. In the second case, a 53-year-old female with a recurrent left frontal cerebral metastasis developed a large cystic lesion 30 months post ablation. Both patients required craniotomies and resection of their cystic lesions. In both cases pathology demonstrated reactive gliosis and blood vessel sclerosis. We hypothesize chronic gliosis following LITT therapy results in blood vessel sclerosis leading to blood-brain barrier-breakdown and delayed cyst formation. These findings support the need for long-term surveillance of patients treated with LITT.