Colorectal cancer: the APC-lncRNA link.
editorial · Level V
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- Record sourced from PubMed, PMID 30640173.
- Also identified by DOI 10.1172/JCI125985 and PMC identifier 6355233.
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Abstract
The adenomatous polyposis coli (APC) gene plays, among other things, a crucial role in the regulation of cell proliferation and survival through its ability to regulate canonical Wnt signaling. In this issue of the JCI, Wang et al. provide an intriguing new mechanism for APC function involving the regulation of a novel long noncoding RNA (lncRNA), leading to changes in exosome production. APC signaling via this novel pathway can regulate cell proliferation and invasion as well as angiogenesis. In addition to enhancing our understanding of APC function, this new mechanism is of particular clinical significance, as it may provide additional targets for the treatment of APC-mutated cancers.
Medical subject headings
- Adenomatous Polyposis Coli
- Colorectal Neoplasms
- Exosomes
- RNA, Long Noncoding