No Cell Left Unturned: Intraductal Papillary Mucinous Neoplasm Heterogeneity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30642914.
- Also identified by DOI 10.1158/1078-0432.CCR-18-3877 and PMC identifier 6445728.
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Abstract
Intraductal papillary mucinous neoplasm (IPMN) is a pancreatic cancer precursor lesion with established genetic features, but the cellular ecosystem of these tumors remains to be fully characterized. This study utilizes single-cell RNA sequencing to describe the dynamic landscape of epithelial, immune, and stromal cells during IPMN progression to invasive cancer.<i>See related article by Bernard et al., p. 2194</i>.
Medical subject headings
- Adenocarcinoma, Mucinous
- Carcinoma, Pancreatic Ductal
- Gastrointestinal Neoplasms
- Pancreatic Neoplasms