The SPECTRA Collaboration OMERACT Working Group: Construct Validity of Joint Space Outcomes with High-resolution Peripheral Quantitative Computed Tomography.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 30647172.
- Also identified by DOI 10.3899/jrheum.180870.
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Abstract
We assessed construct validity of high-resolution peripheral quantitative computed tomography (HR-pQCT) joint space outcomes by comparison with radiographs in patients with rheumatoid arthritis. In 43 patients, quantitative, volumetric, HR-pQCT measurements were compared with ordinal Sharp/van der Heijde scoring (SvdH) in the 2nd and 3rd metacarpophalangeal joints. Generalized estimating equations showed that joint space minimum, SD, and asymmetry by HR-pQCT were associated with SvdH scores (p < 0.05). There was a considerable range in HR-pQCT measurements at SvdH equal to 0. HR-pQCT demonstrated construct validity outcomes and provides improved 3-D visualization of joint space.
Medical subject headings
- Arthritis, Rheumatoid
- Metacarpophalangeal Joint
- Outcome Assessment, Health Care
- Radiography
- Tomography, X-Ray Computed