Shiftwork and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 30649009.
- Also identified by DOI 10.1097/JOM.0000000000001541 and PMC identifier 6610651.
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Abstract
To assess the association of shiftwork with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort. A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification. Associations were observed between day and night shiftworkers for leukocytes, tumor necrosis factor alpha, and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shiftworkers with a BMI more than or equal to 30 kg/m versus the day shift. Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shiftwork.
Medical subject headings
- Biomarkers
- Cardiovascular Diseases
- Work Schedule Tolerance