Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children.

Guilbert, Theresa W; Bacharier, Leonard B; Mauger, David T; Phipatanakul, Wanda; Szefler, Stanley J; Boehmer, Susan; Beigelman, Avraham; Fitzpatrick, Anne M et al. · J Allergy Clin Immunol · 2019

Level V

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Abstract

This letter addresses the controversial issue of the use of oral corticosteroids during wheezing exacerbations in preschool-aged children by demonstrating findings of a prematurely terminated multi-center clinical trial, discussing lessons learned, and suggesting future directions.

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