TRPC6 in diabetic kidney disease: good guy or bad guy?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30665563.
- Also identified by DOI 10.1016/j.kint.2018.10.027 and PMC identifier 6800994.
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Abstract
An association of altered activity of transient receptor potential cation channel C6 (TRPC6) with the development of various diabetic complications was previously reported. In this issue, Wang et al. tested the contribution of TRPC6 in type 1 diabetes setting by breeding Akita mice with TRPC6 knockout mice. The authors revealed that the knockout of TRPC6 decreased proteinuria and attenuated tubule injury but promoted mesangial expansion in Akita mice. Therefore, TRPC6 has both beneficial and detrimental effects on glomeruli function.
Medical subject headings
- Diabetic Nephropathies
- Insulin Resistance