Fitness genes of group A streptococci in necrotizing fasciitis and myositis.
other · Level V
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- Record sourced from PubMed, PMID 30667379.
- Also identified by DOI 10.1172/JCI126482 and PMC identifier 6355235.
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Abstract
Necrotizing fasciitis and myositis caused by group A streptococci (GAS) are among the most fulminating infections, with a mortality rate of 20% to 30%. Although numerous regimens have been utilized in attempts to control these devastating infections, such as combinations of various antimicrobial agents and intravenous immunoglobulin (IVIG) as well as hyperbaric oxygen therapy, none have been the complete answer. Zhu and colleagues have utilized a transposon-directed insertion-site sequencing (TraDIS) protocol to identify 126 genes of M1 and 116 genes of M28 strains of GAS required for myositis, of which 25% encode transporters, which could be used as possible targets for future therapeutic protocols.
Medical subject headings
- Fasciitis, Necrotizing
- Myositis