Depression Stresses the Immune Response and Promotes Prostate Cancer Growth.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30670491.
- Also identified by DOI 10.1158/1078-0432.CCR-18-3980 and PMC identifier 6467802.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Depression induces secretion of neuropeptide Y from prostate cancer cells, which, in turn, recruits myeloid-derived suppressor cells (MDSC) to the tumor; tumor cells and MDSCs secrete IL6, which activates STAT3 within cancer cells. Prostate cancer samples from depressed patients reveal a similar phenotype, suggesting new treatment strategies based upon blockade of β2-adrenergic receptors and/or neuropeptide Y.<i>See related article by Cheng et al., p. 2621</i>.
Medical subject headings
- Myeloid-Derived Suppressor Cells
- Prostatic Neoplasms