Fluorescent reconstitution on deposition of PM<sub>2.5</sub> in lung and extrapulmonary organs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30692265.
- Also identified by DOI 10.1073/pnas.1818134116 and PMC identifier 6377456.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The deposition of PM<sub>2.5</sub> (fine particulate matter in air with diameter smaller than 2.5 μm) in lungs is harmful to human health. However, real-time observation on the deposition of particles in the acinar area of the lung is still a challenge in experiments. Here, a fluorescent imaging method is developed to visualize the deposition process with a high temporal and spatial resolution. The observations reveal that the deposition pattern is nonuniform, and the maximum deposition rate in the acinar area differs significantly from the prediction of the widely used average deposition model. The method is also used to find single particles in the kidney and liver, though such particles are commonly believed to be too large to enter the extrapulmonary organs.
Medical subject headings
- Kidney
- Liver
- Microscopy, Fluorescence
- Particulate Matter
- Pulmonary Alveoli