Visible light-induced direct α C-H functionalization of alcohols.
basic_science · Level V
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- Record sourced from PubMed, PMID 30692540.
- Also identified by DOI 10.1038/s41467-019-08413-9 and PMC identifier 6349847.
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Abstract
Considering the synthetic value of introducing active alcoholic hydroxyl group, developing C-H functionalization of alcohols is of significance. Herein, we present a photochemical method that under visible light irradiation, selectfluor can effectively promote the oxidative cross-coupling between alcohols and heteroarenes without the external photocatalysis, achieving the selective α sp<sup>3</sup> C-H arylation of alcohol, even in the presence of ether. The N-F activation of selectfluor under blue LEDs irradiation is evidenced by electron paramagnetic resonance (EPR) study, which is the key process for the oxidative activation of α sp<sup>3</sup> C-H alcohols. The observed reactivity may have significant implications for chemical transformations.