Improved Outcomes With High-dose Isoniazid in Multidrug-resistant Tuberculosis Treatment in Haiti.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 30698688.
- Also identified by DOI 10.1093/cid/ciz039 and PMC identifier 7322692.
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Abstract
We report outcomes for a cohort of patients with multidrug-resistant tuberculosis who received high-dose isoniazid in Haiti. Patients who received high-dose isoniazid had a faster time to culture conversion and higher odds of successful outcome, despite high-level isoniazid resistance. This suggests high-dose isoniazid may have effectiveness even with phenotypic resistance.
Medical subject headings
- Antitubercular Agents
- Isoniazid
- Tuberculosis, Multidrug-Resistant