CD8+ T-Cell-Derived Tumor Necrosis Factor Can Induce Tissue Factor Expression on Monocytes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30698729.
- Also identified by DOI 10.1093/infdis/jiz051 and PMC identifier 6548895.
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Abstract
Circulating CD8+ T cells and monocytes are activated during human immunodeficiency virus (HIV) infection and colocalize in the aortas of simian immunodeficiency virus-infected nonhuman primates. We hypothesized that CD8+ T cells could exert a proatherosclerotic effect via paracrine actions on monocytes. We found that T-cell receptor-stimulated CD8+ T cells induce monocytes to express tissue factor, a potent activator of coagulation. Tumor necrosis factor was both necessary and sufficient for this effect.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Monocytes
- Thromboplastin
- Tumor Necrosis Factor-alpha