Top-Down Garbage Collector: a tool for selecting high-quality top-down proteomics mass spectra.
other · Level V
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- Record sourced from PubMed, PMID 30715205.
- Also identified by DOI 10.1093/bioinformatics/btz085.
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Abstract
We present the first tool for unbiased quality control of top-down proteomics datasets. Our tool can select high-quality top-down proteomics spectra, serve as a gateway for building top-down spectral libraries and, ultimately, improve identification rates. We demonstrate that a twofold rate increase for two E. coli top-down proteomics datasets may be achievable. http://patternlabforproteomics.org/tdgc, freely available for academic use. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Proteomics