mTOR Is Key to T Cell Transdifferentiation.
Where this comes from
- Record sourced from PubMed, PMID 30726756.
- Also identified by DOI 10.1016/j.cmet.2019.01.008 and PMC identifier 6556472.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
T cell transdifferentiation to functionally distinct subsets can play a key role in balancing the protective and pathogenic features of the T cell response. In a new study, Karmaus et al. (2019) showed that mTORC1 activity influences metabolic heterogeneity within a T cell population to modulate transdifferentiation and disease pathogenesis in a setting of chronic inflammation-driven autoimmunity.
Medical subject headings
- Cell Transdifferentiation
- Th17 Cells