Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 30733412.
- Also identified by DOI 10.1126/science.aav6618 and PMC identifier 8221194.
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Abstract
The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.
Medical subject headings
- Antibodies, Viral
- Cross Reactions
- Dengue
- Viral Nonstructural Proteins
- Zika Virus Infection