Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.
basic_science · Level V
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- Record sourced from PubMed, PMID 30735487.
- Also identified by DOI 10.1371/journal.pone.0198149 and PMC identifier 6368284.
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Abstract
Palmitoylation is an important posttranslational modification regulating diverse cellular functions. Consequently, aberrant palmitoylation can lead to diseases such as neuronal disorders or cancer. In humans there are roughly one hundred times more palmitoylated proteins than enzymes catalyzing palmitoylation (palmitoyltransferases). Therefore, it is an important challenge to establish the links between palmitoyltransferases and their targets. From publicly available data, we find that expression of human ZDHHC8 correlates significantly with cancer survival. To elucidate the organismal function of ZDHHC8, we study the Drosophila ortholog of hZDHHC8, CG34449/dZDHHC8. Knockdown of dZDHHC8 causes tissue overgrowth while dZDHHC8 mutants are larval lethal. We provide a list of 159 palmitoylated proteins in Drosophila and present data suggesting that scribble and Ras64B are targets of dZDHHC8.
Medical subject headings
- Acyltransferases
- Drosophila Proteins
- Membrane Proteins
- ras Proteins