Replication Timing Becomes Intertwined with 3D Genome Organization.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30735630.
- Also identified by DOI 10.1016/j.cell.2019.01.027.
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Abstract
Through dissecting the link between spatial genome organization and DNA replication timing, Sima et al. (2018) discover early replicating control elements (ERCEs), a new type of cis-acting elements that regulate replication timing, transcription, and multiple layers of three-dimensional features of genome organization. The study has important implications for unraveling control elements of high-order genome structure and function.
Medical subject headings
- DNA Replication
- DNA Replication Timing