Lysosomes Dare Cells to be Different(iated).
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30735644.
- Also identified by DOI 10.1016/j.stem.2019.01.007.
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Abstract
In this issue of Cell Stem Cell, Villegas et al. (2019) used a genome-wide CRISPR screen to identify ESC pluripotency regulators, which generated insights into how signaling from lysosome enables cells to transcriptionally regulate their metabolism. Further investigation of human genetics identified a human developmental disease arising from a defect in this process.
Medical subject headings
- Embryonic Stem Cells
- Pluripotent Stem Cells