Unraveling Difficult Answers: From Genotype to Phenotype in Coronary Artery Disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30735646.
- Also identified by DOI 10.1016/j.stem.2019.01.008 and PMC identifier 7375859.
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Abstract
Genome-wide association studies (GWASs) have robustly found a correlation between coronary artery disease (CAD) and an intergenic region at locus 9p21.3. However, the mechanistic implication of this association is unknown. Recently in Cell, Lo Sardo et al. used hiPSC genome editing to demonstrate how this locus contributes to CAD predisposition.
Medical subject headings
- Cardiovascular Diseases
- Coronary Artery Disease