Transmission-blocking Effects of Primaquine and Methylene Blue Suggest Plasmodium falciparum Gametocyte Sterilization Rather Than Effects on Sex Ratio.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30753355.
- Also identified by DOI 10.1093/cid/ciz134 and PMC identifier 6763632.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Gametocyte density and sex ratio can predict the proportion of mosquitoes that will become infected after feeding on blood of patients receiving nongametocytocidal drugs. Because primaquine and methylene blue sterilize gametocytes before affecting their density and sex ratio, mosquito feeding experiments are required to demonstrate their early transmission-blocking effects.
Medical subject headings
- Antimalarials
- Culicidae
- Malaria, Falciparum
- Methylene Blue
- Plasmodium falciparum
- Primaquine