Finding enzyme cofactors in Protein Data Bank.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30759194.
- Also identified by DOI 10.1093/bioinformatics/btz115 and PMC identifier 6748742.
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Abstract
Cofactors are essential for many enzyme reactions. The Protein Data Bank (PDB) contains >67 000 entries containing enzyme structures, many with bound cofactor or cofactor-like molecules. This work aims to identify and categorize these small molecules in the PDB and make it easier to find them. The Protein Data Bank in Europe (PDBe; pdbe.org) has implemented a pipeline to identify enzyme cofactor and cofactor-like molecules, which are now part of the PDBe weekly release process. Information is made available on the individual PDBe entry pages at pdbe.org and programmatically through the PDBe REST API (pdbe.org/api). Supplementary data are available at Bioinformatics online.
Medical subject headings
- Databases, Protein