Neuro-oncology: Implications of the molecular era.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30760635.
- Also identified by DOI 10.1212/WNL.0000000000007126.
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Abstract
The field of neuro-oncology has recently experienced a renaissance in the understanding of the molecular underpinnings and pathophysiology of glioma. Genetic markers have significant implications regarding treatment responsiveness and prognosis and are now the primary basis for classification. This article gives an updated understanding of the pathogenesis and mechanisms of resistance of glioma via discussion of 4 molecular and genetic markers: MGMT, <i>IDH</i>, 1p/19q, and <i>TERT</i>.
Medical subject headings
- Brain Neoplasms
- Glioma