Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30763072.
- Also identified by DOI 10.1021/acsnano.8b08398.
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Abstract
Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep-tissue and highly spatiotemporally precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen (<sup>1</sup>O<sub>2</sub>) generation efficiency and large two-photon absorption (2PA) cross-sections are highly desirable, but the availability of such PSs is limited by challenges in molecular design. In this work, we report that the polymerization of small-molecule PSs with aggregation-induced emission (AIE) could yield conjugated polymer PSs with good brightness, high <sup>1</sup>O<sub>2</sub> generation efficiency, and large 2PA cross-sections. A pair of conjugated polymer PSs were designed and synthesized, and the corresponding AIE PS dots were prepared by nanoprecipitation, which exhibited outstanding 2PE-PDT performance in in vitro cancer cell ablation and in vivo zebrafish liver tumor treatment. Our work highlights a strategy to design highly efficient PSs for 2PE-PDT.
Medical subject headings
- Antineoplastic Agents
- Liver Neoplasms
- Photochemotherapy
- Photons
- Photosensitizing Agents
- Precision Medicine