ATM Inhibition Sensitizes Tumors to High-Dose Irradiation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30770366.
- Also identified by DOI 10.1158/0008-5472.CAN-18-4072.
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Abstract
Mechanistic studies of high-dose irradiation are important to improve our understanding on how the efficacy of stereotactically delivered high-dose irradiation can be enhanced by therapeutics such as ataxia-telangiesctasia-mutated (ATM) inhibitors. In this issue of <i>Cancer Research</i>, Torok and colleagues found that a single 15 Gy radiation dose eliminated lung tumor growth in mice when ATM was deleted in cancer cells versus when deleted in endothelial cells. These data support the establishment of clinical trials testing ATM inhibitors in combination with highly conformal radiotherapy or high-dose rate brachytherapy.<i>See related article by Torok et al., p. 773</i>.
Medical subject headings
- Adenocarcinoma of Lung
- Lung Neoplasms