Adaptive Trial Designs in Rheumatology: Report from the OMERACT Special Interest Group.
systematic_review · Level I
Where this comes from
- Record sourced from PubMed, PMID 30770514.
- Also identified by DOI 10.3899/jrheum.181054.
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Abstract
Adaptive trial design was developed initially for oncology to improve trial efficiency. If optimized for rheumatology, it may improve trial efficiency by reducing sample size and time. A systematic review assessed design of phase II clinical trials in rheumatoid arthritis. Fifty-six trials were reviewed. Most trials had 4 groups (1 control and 3 intervention), with an average group size of 34 patients. American College of Rheumatology 20 measured at 16 weeks was the most commonly used primary endpoint. The next step is to undertake a systematic review of adaptive designs used in early-phase trials in nonrheumatic conditions.
Medical subject headings
- Antirheumatic Agents
- Arthritis, Rheumatoid
- Clinical Trials as Topic
- Research Design
- Rheumatology