B cells in Sjögren's syndrome: from pathophysiology to therapeutic target.
review · Level V
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- Record sourced from PubMed, PMID 30770916.
- Also identified by DOI 10.1093/rheumatology/key332.
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Abstract
Biological abnormalities associated with B lymphocytes are a hallmark of patients with primary Sjögren's syndrome. Those patients present abnormal distribution of B lymphocytes in peripheral blood and B cells in exocrine glands. B cells produce auto-antibodies, cytokines and present antigens but can also suppressive functions. In this review, we will summarize current knowledge on B cells in primary Sjögren's syndrome patients, demonstrate their critical role in the immunopathology of the disease and describe the past and current trials targeting B cells.