Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30772601.
- Also identified by DOI 10.1016/j.bone.2019.02.013.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
MicroRNA (miRNA) has shown to enhance or inhibit cell proliferation, differentiation and activity of different cell types in bone tissue. The discovery of miRNA actions and their targets has helped to identify them as novel regulations actors in bone. Various studies have shown that miRNA deregulation mediates the progression of bone-related pathologies, such as osteoporosis. The present review intends to give an exhaustive overview of miRNAs with experimentally validated targets involved in bone homeostasis and highlight their possible role in osteoporosis development. Moreover, the review analyzes miRNAs identified in clinical trials and involved in osteoporosis.
Medical subject headings
- Bone and Bones
- Epigenesis, Genetic
- Gene Expression Regulation
- MicroRNAs
- Osteoporosis