Tubule repair: with a little help from my "unexpected" friends.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30784654.
- Also identified by DOI 10.1016/j.kint.2018.11.019.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Tubulointerstitial fibrosis is considered a hallmark of maladaptive repair processes after tubular injury leading to chronic kidney disease. Nakamura and colleagues show that, upon injury, myofibroblasts promote epithelial repair by producing retinoic acid in place of injured tubular cells. These results suggest that resident fibroblasts turning into myofibroblasts maintain a cross-talk that protects tubular epithelial cells from injury and can restore tissue integrity and functionality, challenging the concept that fibrosis is only detrimental in nature.
Medical subject headings
- Myofibroblasts
- Tretinoin