Kidney aging: an irresistible slope.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30784656.
- Also identified by DOI 10.1016/j.kint.2018.11.036.
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Abstract
Kidney aging is a multifactorial process. Using genome-wide database analysis, Rowland et al. identified testis-specific Y-encoded-like protein 5 as a candidate age-related renal gene, and reported that with aging, testis-specific Y-encoded-like protein 5 expression decreases in response to increased testis-specific Y-encoded-like protein 5 promoter methylation. Genome-wide databases are readily available, and we should carefully analyze them to find a mechanism to fight kidney aging on the experiments using cells and animals, not just in silico calculations.
Medical subject headings
- DNA Methylation
- Epigenomics