Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model.
basic_science · Level V
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- Record sourced from PubMed, PMID 30785960.
- Also identified by DOI 10.1371/journal.pone.0212663 and PMC identifier 6382128.
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Abstract
As Alzheimer's disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ42 peptide and inhibited the inflammatory response in primary cellular model of AD. Here, effects of this stilbenoid were evaluated in transgenic APPswePS1dE9 mice. We report that trans ε-viniferin could go through the blood brain barrier, reduces size and density of amyloid deposits and decreases reactivity of astrocytes and microglia, after a weekly intraperitoneal injection at 10 mg/kg from 3 to 6 months of age.
Medical subject headings
- Alzheimer Disease
- Benzofurans
- Inflammation
- Plaque, Amyloid
- Stilbenes