LIONS: analysis suite for detecting and quantifying transposable element initiated transcription from RNA-seq.
basic_science · Level V
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- Record sourced from PubMed, PMID 30793157.
- Also identified by DOI 10.1093/bioinformatics/btz130.
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Abstract
Transposable elements (TEs) influence the evolution of novel transcriptional networks yet the specific and meaningful interpretation of how TE-derived transcriptional initiation contributes to the transcriptome has been marred by computational and methodological deficiencies. We developed LIONS for the analysis of RNA-seq data to specifically detect and quantify TE-initiated transcripts. Source code, container, test data and instruction manual are freely available at www.github.com/ababaian/LIONS. Supplementary data are available at Bioinformatics online.
Medical subject headings
- DNA Transposable Elements