Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30794656.
- Also identified by DOI 10.1371/journal.pone.0212736 and PMC identifier 6386501.
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Abstract
Salicylic acid (SA) is an effective elicitor to increase taxol production in Pestalotiopsis microspora. Addition of SA at the concentration of 300 μM yielded taxol 625.47 μg L-1, 45- fold higher than that of the control. Elicitation of the role of SA in the fungal taxol biosynthetic pathway revealed that SA enhanced reactive oxygen species and lipid peroxidation of unsaturated fatty acids of P. microspora mycelia. This oxidative process stimulates isoprene biosynthetic pathway by triggering expression of the geranylgeranyl pyrophosphate synthase gene leading to improved biosynthesis of taxol in P. microspora.
Medical subject headings
- Ascomycota
- Paclitaxel
- Salicylic Acid