Dissecting Cell Lineages: From Microscope to Kaleidoscope.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30794779.
- Also identified by DOI 10.1016/j.cell.2019.01.054.
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Abstract
Single-cell transcriptomics coupled with dynamic two-color fluorescence are used by Gehart et al. (2019) to elucidate adult mammalian cell trajectories in real time. The authors' close examination of intestinal enteroendocrine differentiation reveals new lineage features and shifting cell identities, and experiments in organoids uncover specific roles for transcriptional regulators identified by this approach.
Medical subject headings
- Organoids
- Stem Cells