Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF.
Level V
Where this comes from
- Record sourced from PubMed, PMID 30796980.
- Also identified by DOI 10.1016/j.jaci.2019.02.007 and PMC identifier 7610814.
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Abstract
This mouse study demonstrates that repetitive inhalation of a single major house dust mite (HDM) allergen prevents HDM-induced allergic asthma development through suppressing the function of lung dendritic cells, thus providing an alternative to classical allergen-specific immunotherapy.
Medical subject headings
- Allergens
- Antigens, Dermatophagoides
- Arthropod Proteins
- Asthma
- Desensitization, Immunologic
- Granulocyte-Macrophage Colony-Stimulating Factor
- Lung