Quadruplex knots as network nodes: nano-partitioning of guanosine derivates in supramolecular hydrogels.
basic_science · Level V
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- Record sourced from PubMed, PMID 30806419.
- Also identified by DOI 10.1039/c8sm02616e.
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Abstract
Aqueous solutions of guanosine-5'-monophosphates (GMP) - known to form G-quadruplexes and liquid crystal phases - can be induced to turn into high water content gels by the addition of guanosine (Gua). By a combination of Light Scattering (LS) and AFM we show that Gua/GMP hydrogels are microscopically heterogeneous, formed by Gua-rich disordered microcoils of intertwined filaments ("knots") connected by GMP-rich long linear threads. The different thermal stability of knots and threads controls the gel transition.