Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR-132/MeCP2 pathway.
basic_science · Level V
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- Record sourced from PubMed, PMID 30809933.
- Also identified by DOI 10.1111/acel.12929 and PMC identifier 6516177.
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Abstract
Tauopathies are a class of neurodegenerative diseases that are characterized by pathological aggregation of tau protein, which is accompanied by synaptic disorders. However, the role of tau in endocytosis, a fundamental process in synaptic transmission, remains elusive. Here, we report that forced expression of human tau (hTau) in mouse cortical neurons impairs endocytosis by decreasing the level of the GTPase dynamin 1 via disruption of the miR-132-MeCP2 pathway; this process can also be detected in the brains of Alzheimer's patients and hTau mice. Our results provide evidence for a novel role of tau in the regulation of presynaptic function.
Medical subject headings
- Dynamin I
- Endocytosis
- Methyl-CpG-Binding Protein 2
- MicroRNAs
- Neurons
- tau Proteins