The (pro)renin receptor: an emerging player in hypertension and metabolic syndrome.
review · Level V
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- Record sourced from PubMed, PMID 30819554.
- Also identified by DOI 10.1016/j.kint.2018.10.042 and PMC identifier 6478511.
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Abstract
The (pro)renin receptor (PRR) is a multifunctional protein that is expressed in multiple organs. Binding of prorenin/renin to the PRR activates angiotensin II-dependent and angiotensin II-independent pathways. The PRR is also involved in autophagy and Wnt/ß catenin signaling, functions that are not contingent on prorenin binding. Emerging evidence suggests that the PRR plays an important role in blood pressure regulation and glucose and lipid metabolism. Herein, we review PRR function in health and disease, with particular emphasis on hypertension and the metabolic syndrome.
Medical subject headings
- Hypertension
- Metabolic Syndrome
- Proton-Translocating ATPases
- Receptors, Cell Surface
- Renin
- Vacuolar Proton-Translocating ATPases