Nonspecific effects of oral vaccination with live-attenuated <i>Salmonella</i> Typhi strain Ty21a.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 30820452.
- Also identified by DOI 10.1126/sciadv.aau6849 and PMC identifier 6392763.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Epidemiological and immunological evidence suggests that some vaccines can reduce all-cause mortality through nonspecific changes made to innate immune cells. Here, we present the first data to describe the nonspecific immunological impact of oral vaccination with live-attenuated <i>Salmonella</i> Typhi strain Ty21a. We vaccinated healthy adults with Ty21a and assessed aspects of innate and adaptive immunity over the course of 6 months. Changes to monocyte phenotype/function were observed for at least 3 months. Changes to innate and adaptive immune cell cytokine production in response to stimulation with vaccine and unrelated nonvaccine antigens were observed over the 6-month study period. The changes that we have observed could influence susceptibility to infection through altered immune responses mounted to subsequently encountered pathogens. These changes could influence all-cause mortality.
Medical subject headings
- Polysaccharides, Bacterial
- Salmonella typhi
- Typhoid Fever
- Typhoid-Paratyphoid Vaccines
- Vaccination
- Vaccines, Attenuated