Pregnancy Outcomes in Couples with Males Exposed to Longterm Anti-tumor Necrosis Factor-<i>α</i> Inhibitor Therapies: A Prospective Study.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 30824658.
- Also identified by DOI 10.3899/jrheum.180588.
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Abstract
To examine the pregnancy achievement and outcomes in couples in which men with spondyloarthritis (SpA) were exposed to tumor necrosis factor inhibitors (TNFi). Information about pregnancies involving fathers with SpA was prospectively collected by 6 Romanian rheumatology centers. Twenty-seven patients achieved 33 pregnancies and fathered 30 healthy children. Three elective abortions (personal reasons) and no spontaneous abortions, preeclampsia/eclampsia, stillbirths, congenital malformations, or pathologies in the children were recorded. Five patients showed normospermia before and after longterm TNFi treatment. Pregnancy and child outcomes in male patients with SpA exposed to longterm TNFi therapy were reassuring.
Medical subject headings
- Antirheumatic Agents
- Paternal Exposure
- Spondylarthritis
- Tumor Necrosis Factor Inhibitors