T-cell mitochondrial dysfunction and lymphopenia in DOCK2-deficient patients.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 30826364.
- Also identified by DOI 10.1016/j.jaci.2019.02.020 and PMC identifier 6612298.
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Abstract
This study delineates the mitochondrial defects in DOCK2-deficient T cells contributing to the T cell lymphopenia characteristic of this primary immunodeficiency.
Medical subject headings
- GTPase-Activating Proteins
- Guanine Nucleotide Exchange Factors
- Immunologic Deficiency Syndromes
- Mitochondria
- T-Lymphocytes