Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 30828886.
- Also identified by DOI 10.1002/hed.25733 and PMC identifier 6766850.
- Licence recorded as CC BY-NC-ND.
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Abstract
The purpose of this study was to determine the additional diagnostic value of squamous cell carcinoma antigen (SCC-Ag) in cervical lymph node fine needle aspiration (FNA) samples for the detection of regional metastases of head and neck squamous cell carcinoma (HNSCC). In 149 FNA samples of 114 patients, SCC-Ag concentration was retrospectively analyzed and associated with diagnosis to establish a cutoff concentration in relation to sensitivity and specificity of HNSCC detection. SCC-Ag was elevated in lymph nodes from patients with HNSCC compared to lymph nodes from other patients (P < 0.01). With 0.3 μg/L as the cutoff concentration, SCC-Ag has 96% sensitivity for detecting HNSCC. SCC-Ag in FNA is a reliable test for detecting HNSCC in cervical lymph nodes.
Medical subject headings
- Antigens, Neoplasm
- Carcinoma, Squamous Cell
- Head and Neck Neoplasms
- Lymph Nodes
- Lymphatic Metastasis