A New Transkingdom Dimension to NO Signaling.
editorial · Level V
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- Record sourced from PubMed, PMID 30840909.
- Also identified by DOI 10.1016/j.cmet.2019.02.008.
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Abstract
Bacterial-derived metabolites profoundly influence the host's cellular and organismal physiology. Seth et al. (2019) report that via interspecies S-nitrosylation, microbiota-derived nitric oxide directly alters the host's Argonaute family protein activity, and consequently impinges on the overall post-transcriptional gene silencing program through the microRNA (miRNA) machinery.
Medical subject headings
- MicroRNAs
- Nitric Oxide