Close Quarters Can Be a Good Fit for Stem Cells to Become T Cells.

Trotman-Grant, Ashton; Zúñiga-Pflücker, Juan Carlos · Cell Stem Cell · 2019

editorial · Level V

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Abstract

Human pluripotent stem cells (PSCs) could potentially provide a potentially unlimited supply of T cells. In this issue of Cell Stem Cell, Montel-Hagen et al. (2019) take advantage of a three-dimensional mouse stromal cell-based system that combines mesoderm specification with organoid-induced hematopoietic differentiation to enable commitment, selection, and maturation of conventional human T cells.

Medical subject headings