Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30849361.
- Also identified by DOI 10.1016/j.stem.2019.02.003.
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Abstract
Conflicting clinical studies have reported that statins both reduce and accelerate cognitive impairments in Alzheimer's disease. In this issue, Van der Kant et al. (2019) use iPSC-derived neurons to thoroughly dissect the link between cholesterol synthesis, phospho-Tau, and amyloid-β, revealing new therapeutic opportunities in Alzheimer's disease and related dementias.
Medical subject headings
- Alzheimer Disease
- Hydroxymethylglutaryl-CoA Reductase Inhibitors