Stem Cell Aging? Blame It on the Niche.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30849364.
- Also identified by DOI 10.1016/j.stem.2019.02.011.
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Abstract
The molecular basis for the neural stem cell quiescence-to-activation transition has become an important focus in the study of adult neurogenesis. Recently in Cell, Kalamakis et al. (2019) show that aged neural stem cells face greater barriers to exiting quiescence, imposed by the niche through inflammation and altered Wnt signaling.
Medical subject headings
- Neural Stem Cells
- Stem Cell Niche