Dynamic Changes in the Niche with N-Cadherin Revisited: The HSC "Niche Herein".
editorial · Level V
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- Record sourced from PubMed, PMID 30849365.
- Also identified by DOI 10.1016/j.stem.2019.02.007.
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Abstract
Recently in Cell Reports, Zhao et al. report that chemo-resistant (reserve) hematopoietic stem cells (HSCs) are maintained in the endosteal niche under the influence of N-cadherin+ bone-lining cells (Zhao et al., 2019). These findings further indicate that niches for bone marrow HSCs may differ dynamically during physiological and stress hematopoiesis.
Medical subject headings
- Bone Marrow
- Cadherins