An Error-Prone Polymerase in the Fight against Cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30849368.
- Also identified by DOI 10.1016/j.cell.2019.02.011.
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Abstract
Error-prone polymerases are alleged to induce mutations while replicating damaged DNA and to increase the risk of cancer. Using in vitro studies and mice models, Yoon et al. (2019) provide evidence that the error-prone Pol θ polymerase protects against ultraviolet light-induced skin cancer despite its mutagenic potential.
Medical subject headings
- Skin Neoplasms
- Ultraviolet Rays