Are Many Patients Diagnosed With Healthcare-associated Clostridioides difficile Infections Colonized With the Infecting Strain on Admission?

Gonzalez-Orta, Melany; Saldana, Carlos; Ng-Wong, Yilen; Cadnum, Jennifer; Jencson, Annette; Jinadatha, Chetan; Donskey, Curtis J · Clin Infect Dis · 2019

prospective_cohort · Level II

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Abstract

In a cohort of 480 patients admitted to an acute care hospital, 68 (14%) had positive perirectal cultures for toxigenic Clostridioides difficile on admission. Of the 11 patients (2%) diagnosed with healthcare-associated C. difficile infections, 3 (27%) had genetically related admission and infection isolates, based on whole-genome sequencing.

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