Galectin-3 is essential for IgE-dependent activation of human basophils by A549 lung epithelial cells.
Where this comes from
- Record sourced from PubMed, PMID 30857982.
- Also identified by DOI 10.1016/j.jaci.2019.03.001 and PMC identifier 6612293.
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Abstract
Using novel co-culture model systems, galectin-3 is shown to facilitate basophil secretion of IL-4/IL-13, with implications that this unique mode of activation may be linked to a variety of diseases ranging from asthma to cancer.
Medical subject headings
- Basophils
- Galectin 3
- Immunoglobulin E